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NCRR's Division of Comparative Medicine helps meet the needs of biomedical researchers for high-quality, disease-free animals and specialized animal research facilities.

NCRR's Division of Comparative Medicine helps meet the needs of biomedical researchers for high-quality, disease-free animals and specialized animal research facilities.

NCRR's Division of Comparative Medicine helps meet the needs of biomedical researchers for high-quality, disease-free animals and specialized animal research facilities.

NCRR's Division of Comparative Medicine helps meet the needs of biomedical researchers for high-quality, disease-free animals and specialized animal research facilities.

NCRR's Division of Comparative Medicine helps meet the needs of biomedical researchers for high-quality, disease-free animals and specialized animal research facilities.

Comparative Medicine

WEB SHORTCUT: NCRR.NIH.GOV/CM

Results

A quarterly digest of research supported by NCRR's Division of Comparative Medicine

Roles of brca2 (fancd1) in Oocyte Nuclear Architecture, Gametogenesis, Gonad Tumors, and Genome Stability in Zebrafishexternal link, opens in new window
PLoS Genet. 2011 Mar;7(3):e1001357

Structure and sequence of the saimiriine herpesvirus 1 genomeexternal link, opens in new window
Virology. 2011 Feb 5;410(1):181-9

A toll-like receptor-4-interacting surfactant protein-A-derived peptide suppresses tumor necrosis factor-a release from mouse JAWS II dendritic cellsexternal link, opens in new window
J Pharmacol Exp Ther. 2011 Mar;336(3):672-81

Infection, Viral Dissemination, and Antibody Responses of Rhesus Macaques Exposed to the Human Gammaretrovirus XMRVexternal link, opens in new window
J Virol. 2011 May;85(9):4547-57

Detection of CWD prions in salivary, urinary, and intestinal tissues of deer: potential mechanisms of prion shedding and transmissionexternal link, opens in new window
J Virol. 2011 Jul;85(13):6309-18

Japanese macaque encephalomyelitis: A spontaneous multiple sclerosis-like disease in a nonhuman primateexternal link, opens in new window
Ann Neurol. 2011 Apr 7. doi: 10.1002/ana.22449

Genomic analysis reveals pre- and postchallenge differences in a rhesus macaque AIDS vaccine trial: insights into mechanisms of vaccine efficacyexternal link, opens in new window
J Virol. 2011 Jan;85(2):1099-116

Pandemic swine-origin H1N1 influenza A virus isolates show heterogeneous virulence in macaquesexternal link, opens in new window
J Virol. 2011 Feb;85(3):1214-23

Low levels of SIV infection in sooty mangabey central memory CD4(+) T cells are associated with limited CCR5 expressionexternal link, opens in new window
Nat Med. 2011 Jun 26;17(7):830-6

Acute hepatitis A virus infection is associated with a limited type I interferon response and persistence of intrahepatic viral RNAexternal link, opens in new window
Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11223-8

Cross-species transmission of a novel adenovirus associated with a fulminant pneumonia outbreak in a new world monkey colonyexternal link, opens in new window
PLoS Pathog. 2011 Jul;7(7):e1002155

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccineexternal link, opens in new window
Nature. 2011 May 26;473(7348):523-7

Maternal high-fat diet disturbs uteroplacental hemodynamics and increases the frequency of stillbirth in a nonhuman primate model of excess nutritionexternal link, opens in new window
Endocrinology. 2011 Jun;152(6):2456-64

Aging of the cerebral cortex differs between humans and chimpanzeesexternal link, opens in new window
Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13029-34

Spontaneous prosocial choice by chimpanzeesexternal link, opens in new window
Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13847-51

Generating gene knockout rats by homologous recombination in embryonic stem cellsexternal link, opens in new window
Nat Protoc. 2011 Jun;6(6):827-44

Beyond knockout rats: new insights into finer genome manipulation in ratsexternal link, opens in new window
Cell Cycle. 2011 Apr 1;10(7):1059-66

Action at a Distance: Systemically Administered Adult Stem/Progenitor Cells (MSCs) Reduce Inflammatory Damage to the Cornea Without Engraftment and Primarily by Secretion of TSG-6external link, opens in new window
Stem Cells. 2011 Aug 11. doi: 10.1002/stem.708

Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-?B signaling in resident macrophagesexternal link, opens in new window
Blood. 2011 Jul 14;118(2):330-8

Mitotic defects lead to pervasive aneuploidy and accompany loss of RB1 activity in mouse LmnaDhe dermal fibroblastsexternal link, opens in new window
PLoS One. 2011 Mar 25;6(3):e18065

Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegenerationexternal link, opens in new window
Proc Natl Acad Sci U S A. 2011 May 17;108(20):8408-13

Changes in melanocortin expression and inflammatory pathways in fetal offspring of nonhuman primates fed a high-fat dietexternal link, opens in new window
Endocrinology. 2010 Apr;151(4):1622-32

Chronic consumption of a high-fat diet during pregnancy causes perturbations in the serotonergic system and increased anxiety-like behavior in nonhuman primate offspringexternal link, opens in new window
J Neurosci. 2010 Mar 10;30(10):3826-30

Epigenetic modification of fetal baboon hepatic phosphoenolpyruvate carboxykinase following exposure to moderately reduced nutrient availabilityexternal link, opens in new window
J Physiol. 2010 Apr 15;588(Pt 8):1349-59

Missing heritability and strategies for finding the underlying causes of complex diseaseexternal link, opens in new window
Nat Rev Genet. 2010 Jun;11(6):446-50

Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory propertiesexternal link, opens in new window
Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13724-9

Endometrial profile of tamoxifen and low-dose estradiol combination therapyexternal link, opens in new window
Clin Cancer Res. 2010 Feb 1;16(3):946-56

The basal ganglia communicate with the cerebellumexternal link, opens in new window
Proc Natl Acad Sci U S A. 2010 May 4; 107(18): 8452–8456

Sm-p80-based DNA vaccine provides baboons with levels of protection against Schistosoma mansoni infection comparable to those achieved by the irradiated cercarial vaccineexternal link, opens in new window
J Infect Dis. 2010 Apr 1;201(7):1105-12

Disheveled hair and ear (Dhe), a spontaneous mouse Lmna mutation modeling human laminopathiesexternal link, opens in new window
PLoS One. 2010 Apr 1;5(4):e9959

See thousands of NCRR-
supported results on the National Library of Medicine's PubMedexternal link, opens in new window

NCRR's Division of Comparative Medicine helps meet the needs of biomedical researchers for high-quality, disease-free animals and specialized animal research facilities. The Division supports both individuals and research organizations.

See the latest news, policies, education and training materials, and information about animals in research on the NIH Medical Research with Animalsexternal link, opens in new window website.

Aquatics

Some aquatic animals serve as models for studying human development, behavior, and disease. With short reproductive cycles and transparent eggs that are easily observed as they develop, Zebrafish are useful for research. Other aquatic models include marine slugs, squid, and octopi.

NCRR's aquatic models program funds development and maintenance of critical genetic stocks, biological materials, and online information for researchers.

Comparative Models

Simpler species such as fruit flies and roundworms are genetically well characterized, inexpensive, and can undergo many genetic manipulations during short periods of time. Results from experiments involving these less complex models can help scientists decide whether to pursue similar research with higher species.

NCRR's comparative models program supports development and use of new and improved animal models that complement those more traditionally used to study human diseases.

Genetic, Biological & Information Resources

NCRR supports a variety of sources for genetic analysis services, biological materials such as cultures and reagents, and on-line information about model organisms.

Nonhuman Primates

Nonhuman primates such as rhesus monkeys are critical for biomedical research because of their close physiological similarities to humans. They enable discoveries that apply directly to studies on human health and help scientists test treatments for health conditions such as drug addiction, obesity, malaria, and AIDS.

NCRR's nonhuman primate program funds animals, facilities, technologies, and materials that support this research. NCRR also is responsible for the National Institutes of Health Chimpanzee Management Program.

Rodents

Rodents play a central role in research that can translate into treatments for human disease. Mice share much in common with human genetics, development, physiology, behavior, and disease and are used to predict promising directions in biomedical research.

NCRR's laboratory rodents program funds development of genetically engineered rodents and research rodent colonies, facilities that distribute rodents and related biological materials, and new ways to study, diagnose, and eliminate laboratory rodent disease.

Small Business Opportunities

NCRR participates in the Small Business Innovation Research (SBIR) Program and the Small Business Technology Transfer (STTR) Program. The Division of Comparative Medicine is especially interested in funding research to develop biomedical methods and technologies that relate to improvements in laboratory animal care, use, and management. READ MORE >>

Career Development Opportunities

Scientists experienced in comparative medicine contribute important expertise to animal, molecular, and genomic studies leading to translational research that benefits human health.

NCRR offers support for individuals, mentors, and institutions intended to enhance the research careers of individuals with D.V.M. or Ph.D. degrees, as well as predoctoral veterinary students.

Support for Conferences and Scientific Meetings

Scientific Conference Grants support national and international meetings sponsored and directed by the R13 grantees. Such meetings must be relevant to the goals of the Division of Comparative Medicine. To ensure the division's interest in the proposed meeting, prospective grantees must contact a program official for written approval prior to submission of an application. If the division determines a sufficient need to have substantial involvement in the planning and conduct of the scientific meeting, then a cooperative agreement (U13)—instead of an R13—would be awarded. READ MOREexternal link, opens in new window

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