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Baylor College of Medicine–Children (Houston)
University of Texas Health Science Center (San Antonio)
University of Texas Medical Branch at Galveston

Baylor College of Medicine–Children

General Clinical Research Center
Texas Children's Hospital
Mail Station I-3420
6621 Fannin Street
Houston, TX 77030

Web site: http://www.bcm.edu/pediatrics/index.cfm external link, opens in new window

Grant No. M01 RR00188

Special Assays, Services, or Tests

Metabolic balances
Neurodevelopmental assessments

Special Resources, Instruments, or Services

Dual-energy X-ray absorptiometry
GC/IR/MS
GC/MS
Gene vector core laboratory
Indirect calorimetry (hood and room)
Instruments and skills for evaluation of health care outcomes and health services delivery
Total-body electrical conductivity analyzer
Whole-body ⁴⁰K counter

Major Areas of Investigation

Allergy and Immunology: AIDS Clinical Trials Group: vertical transmission of AIDS; heart and lung complications; audiologic function; oral manifestations; severe combined immunodeficiency disorders; asthma.

Critical Care: Long-term outcomes of pediatric intensive care unit (PICU) patients; work of breathing and mechanically ventilated patients: gastric intramucosal pH and predictor of cardiac output in children on mechanical ventilation; protein intake and nitrogen balance in PICU patients on total parenteral nutrition.

Endocrinology: Metabolic role of hormones in pubertal growth; effects of hormones on calcium metabolism; studies in clinical disorders of hypopituitarism, Turner's syndrome, diabetes mellitus.

Gene Therapy: Hepatic gene transplantation; gene therapy for pediatric AIDS; urea cycle disorders gene therapy; thymidine kinase gene therapy in children with brain tumors.

Genetic Diseases: Urea cycle disorders; contiguous gene deletion syndromes (Smith-Magenis, Prader-Willi, DiGeorge, Angelmann, Potocki-Shaffer, and Williams syndromes, and Fabry disease).

Infectious Diseases: Maternal-infant cytomegalovirus; Norwalk virus vaccine.

Neonatal Nutrition: Gluconeogenesis in very-low-birthweight infants; Ca and P metabolism and skeletal mineralization; early feeding strategies and development in low-birthweight infants; sulfur amino acid metabolism in low-birthweight infants; quality of energy intake in low-birthweight infants; essential fatty acid metabolism in very-low-birthweight and term infants.

Neurology: Hereditary ataxias; Rett syndrome.

Oncology: Pharmacokinetics of chemotherapy in CNS tumors.

Surgery: Islet cell transplantation.

Contact Information

For information about this GCRC and how to access its resources, please contact:

Administrative Manager
Mahyar Badrei, M.Litt.
832-826-1079; Fax: 832-825-1061
E-mail: mbadrei@txccc.org

Program Director
Dennis M. Bier, M.D.
713-798-7022; Fax: 713-798-7046
E-mail: dbier@bcm.tmc.edu

Principal Investigator
Ralph D. Feigin, M.D.
713-798-4433; Fax: 713-798-8811
E-mail: rfeigin@bcm.tmc.edu

Associate Program Director
Ann R. Stark, M.D.
832-826-1380; Fax: 832-825-2799
E-mail: arstark@bcm.tmc.edu

Associate Program Director
Susan Blaney, M.D.
832-822-1482; Fax: 832-825-4299
E-mail: sblaney@bcm.tmc.edu

Research Subject Advocate
Lisa R. Bomgaars, M.D.
832-824-4629; Fax: 832-825-4039
E-mail: bomgaars@bcm.tmc.edu

GCRC Advisory Committee Chairperson
David G. Poplack, M.D.
832-822-4556; Fax: 832-825-4299
E-mail: dpoplack@bcm.tmc.edu

Nurse Manager, Pediatric Unit
Ellen Pace, B.S.N., R.N.
832-824-1355; Fax: 832-825-1393
E-mail: eapace@texaschildrenshospital.org

Core Laboratory Director
Adrian Gee, Ph.D.
832-824-4214; Fax: 832-825-4668
E-mail: agee@bcm.tmc.edu

Nutritionist
Janice Stuff, Ph.D., R.D.
713-798-7066; Fax: 713-798-7098
E-mail: jstuff@bcm.tmc.edu

Nutritionist
Ann McMeans, M.S., R.D.
832-824-2584; Fax: 832-824-1393
E-mail: amcmeans@bcm.tmc.edu

Biostatistician
Claudia Kozinetz, Ph.D., M.P.H.
832-824-3730; Fax: 832-825-3697
E-mail: kozinetz@bcm.tmc.edu

Biostatistician
E. O'Brian Smith, Ph.D.
713-798-7058; Fax: 713-798-7046
E-mail: esmith@bcm.tmc.edu

University of Texas Health Science Center (San Antonio)

General Clinical Research Center
Department of Medicine/GCRC
Mail Stop 7891
7703 Floyd Curl Drive
San Antonio, TX 78229-3900

Grant No. M01 RR01346

Major Areas of Investigation

Cardiology: Prevention and treatment of acute and chronic heart disease.

Clinical Lab: Use of herbal and other alternative medications.

Diabetes: Pathophysiology and treatment of type 2 diabetes; genetics of diabetes in Mexican Americans; insulin resistance and precursors of diabetes; macrovascular effects of diabetes.

Endocrinology: Genetic and illness-related bone density studies.

Epidemiology: Longitudinal studies of diabetes, aging, atherosclerosis, osteoporosis.

Gynecology:Genetic causes and treatment options for women with polycystic ovary syndrome.

Hematology: Course and management of multiple myeloma.

Infectious Disease: Treatment and outcomes of HIV-related and non-HIV-related tuberculosis.

Nephrology: Family studies of diabetic nephropathy.

Neurology: Neuromuscular disorder and brain tumor research.

Nursing: Nurse-guided exercise regimens for minority females.

Oncology: Phase I studies of anti-cancer drugs.

Pediatrics: Understanding and treatment of genetically caused syndromes.

Pharmacology: Interactions and toleration of new and tested pharmaceuticals.

Physical Therapy/Rehabilitation: Rehabilitation, outcomes, and/or use of prosthetics for persons following stroke, limb loss, etc.

Psychiatry Adolescent, adult disorders and treatments; effect of psychiatric illnesses on physical health.

Pulmonary Disease: Course and management of pulmonary diseases.

Rheumatology and Immunology: Rheumatoid arthritis, effects of rheumatic inflammation on cardiovascular diseases.

Contact Information

For information about this GCRC and how to access its resources, please contact:

Administrative Manager
Susan Stappenbeck, M.Ed., M.P.H.
210-567-4629; Fax: 210-567-4651
E-mail: stappenbeck@uthscsa.edu

Program Director
Michael Lichtenstein, M.D., M.Sc.
210-567-4632; Fax: 210-567-4651
E-mail: lichtenstei@uthscsa.edu

Principal Investigator
Brian Herman, Ph.D.
210-567-2015; Fax: 210-567-2047
E-mail: hermanb@uthscsa.edu

Associate Program Director
Robin Brey, M.D.
210-567-4615; Fax: 210-567-1877
E-mail: brey@uthscsa.edu

Associate Program Director
Agustin Escalante, M.D.
210-567-4658; Fax: 210-567-6853
E-mail: escalante@uthscsa.edu

Research Subject Advocate
Ricardo A. Martinez, Ph.D., R.N.
210-567-4636; Fax: 210-567-4651
E-mail: martinezra0@uthscsa.edu

GCRC Advisory Committee Chairperson
Kenneth Cusi, M.D.
210-567-6691; Fax: 210-567-6554
E-mail: cusi@uthscsa.edu

Imaging Core Director
Peter Fox, M.D.
210-567-8150; Fax: 210-567-8152
E-mail: fox@uthscsa.edu

Bioinformatics and Biostatistics Core Director
Brad Pollock, Ph.D.
210-562-9020; Fax: 210-562-9025
E-mail: bpollock@uthscsa.edu

Nurse Manager
Sharyn Pryor, R.N., M.S.N.
210-617-5300 x4757; Fax: 210-567-0957
E-mail: pryor@uthscsa.edu

Bionutritionist
Celia Darland, R.D., C.D.E.
210-617-5300 x 4755; Fax: 210-567-4651
E-mail: darland@uthscsa.edu

Computer Systems Manager
Karen Schulz, M.S.
210-567-4632; Fax: 210-567-4651
E-mail: schulz@uthscsa.edu

University of Texas Medical Branch at Galveston

General Clinical Research Center
John Sealy Hospital
5th Floor, A and B Units
301 University Boulevard
Galveston, TX 77555-0264

Web site: http://utsouthwestern.edu/utsw/home/research/gcrc external link, opens in new window

Grant No. M01 RR00073

Special Resources, Instruments, or Services

Metabolic control unit
Radiation biophysics laboratory for body composition
Sleep study facility
Volunteer database

Major areas of Investigation

Cancer: Genetic susceptibility to environmental carcinogens; hyperthermia for treatment of advanced cancer.

Cardiopulmonary Disorders: Hypertension; diabetes and cardiovascular disorders; dilated cardiomyopathy and growth hormone; obstructive sleep apnea; warfarin metabolism.

Endocrinology: Insulin resistance, obesity, and diabetes mellitus; growth hormone, androgens, and muscle function in elderly; bone density and hormonal contraception; endocrine complications of closed head injury; endocrine effects of soy diets.

Gastroenterology: Hepatitis C; hepatic steatosis; gastrointestinal myoelectric activity and motility; virtual colonoscopy.

Genetics and Rare Diseases: Human porphyrias; angioneurotic edema; genetic polymorphisms and drug metabolism.

Geriatrics: Androgen deficiency in elderly men; exercise, nutrition, and muscle function in the elderly.

Infectious Diseases: Virologic and immunologic progression in HIV infection; therapies for HIV infection; aging and neuroimmune modulation of viral resistance; genetic and viral influences on otitis media in children; hepatitis C; emerging infectious diseases.

Metabolism: Protein, fat, and carbohydrate metabolism; metabolic effects of burns and stress; effects of nutrition, exercise, and aging on muscle; insulin resistance; bed rest and microgravity; response to bolus intravenous infusions.

Neurology: Hyperglycemia in ischemic stroke; sleep disorders after stroke.

Nutrition: Soy diets, the endocrine system, and breast cancer; differential metabolism of dietary fatty acids.

Space Medicine: Effects of bed rest and microgravity on bone, muscle, and drug metabolism.

Women's Health: Bone density and hormonal contraception; assessment of uterine contractility and cervical ripening to predict delivery; ovarian steroids; diet and risk for breast cancer; effectiveness of pap smear follow-up.

Wound Healing: Metabolic stress and treatment of burned children; childhood psychosocial development, rehabilitation, and sleep abnormalities after burns.

Contact Information

For information about this GCRC and how to access its resources, please contact:

Administrative Manager
Lori A. Wiseman, B.S.
409-772-1953; Fax: 409-772-8097
E-mail: lwiseman@utmb.edu

Program Director
Don W. Powell, M.D.
409-772-9544; Fax: 409-772-8097
E-mail: dpowell@utmb.edu

Principal Investigator
Garland D. Anderson, M.D.
409-772-4793; Fax: 409-772-2684
E-mail: ganderso@utmb.edu

Associate Program Director
Karl E. Anderson, M.D.
409-772-4661; Fax: 409-772-6287
E-mail: kanderso@utmb.edu

Assistant Program Director
Melinda Sheffield-Moore, Ph.D.
409-772-8707; Fax: 409-772-8709
E-mail: melmoore@utmb.edu

Research Subject Advocate
Michele A. Carter, Ph.D.
409-772-1208; Fax: 409-772-8097
E-mail: mcarter@utmb.edu

GCRC Advisory Committee Chairperson
Randall Urban, M.D.
409-772-1176; Fax: 409-772-8762
E-mail: rurban@utmb.edu

Nurse Manager
Margaret Ottenbacher, M.S.N., R.N.
409-772-1619; Fax: 409-772-8097
E-mail: maottenb@utmb.edu

Nutrition Research Manager
Astrid Inniss, Ph.D., R.D., L.D.
409-772-1469; Fax: 409-772-8097
E-mail: aminniss@utmb.edu

Biostatistician
James J. Grady, Dr.P.H.
409-772-5276; Fax: 409-772-9127
E-mail: jgrady@utmb.edu

Computer Systems Manager
Regina K. Minton, B.S.
409-772-6728; Fax: 409-772-8097
E-mail: rkminton@utmb.edu