Ohio

Children's Hospital Medical Center

General Clinical Research Center
Children's Hospital Medical Center
3333 Burnet Avenue
Cincinnati, OH 45229-3039

Web site: www.cincinnatichildrens.org/gcrc

Grant No. M01 RR08084

Special Assays, Services, or Tests

Major Areas of Investigation

Allergy and Immunology: Allergen elimination diets and severity of asthma; effect of intravenous mepolizumab on the outcome and management of hypereosinophilic syndromes.

Cardiology: Cardiovascular risk tracking study; blood pressure divergence in adolescent females; vitamin E intake and oxidized low-density lipoprotein; effect of pre-operative methylprednisolone on inflammatory response following cardiopulmonary bypass; body mass index rebound epidemiology; genetic epidemiology of energy metabolism; neurohormonal activation in single ventricular physiology.

Critical Care Medicine: Adrenal dysfunction in children with septic shock; nitric oxide in infants with respiratory failure.

Developmental Disorders: Human synthetic secretin in children with autism; effect of oral baclofen on function in cerebral palsy.

Endocrinology: Glucagon-like peptide-1 in diabetic and nondiabetic humans, including effects on insulin secretion; mechanisms and implications of discordant hemoglobin A_1c; rhIGF-1 in children with short stature and growth hormone insensitivity syndrome; coronary atherosclerosis in early insulin-dependent diabetes mellitus; sulfonylurea therapy in patients with mutations in the Delta F508 CF transmembrane conductance regulator gene; IGF-1 receptor mutations in human uterine growth retardation; effects of ketogenic diet on body weight/cardiovascular risk factors.

Gastroenterology and Nutrition: Cholera challenge trial; bile acid therapy in treatment of childhood liver disease, including cystic fibrosis, total parenteral nutrition-related cholestasis, and peroxisomal diseases; inborn errors of bile acid metabolism; analysis and physiology of soy isoflavones; cholesterol supplementation and synthesis rates in infants; regulation of plasma cholesterol levels by cholesterol absorption, synthesis, and LDL-receptors; intranasal vitamin B₁₂ dosing interval; rectal bleeding in infants; borderline pancreatic function assessment in cystic fibrosis; role of magnesium in pathogenesis of childhood cholestatic liver disease; reduced bone mass in nonambulatory children and adults; intravenous methylprednisolone versus oral prednisolone in treatment of acute rejection in liver transplant patients; effect of fat ingestion on serum apolipoprotein A-IV levels; pharmacokinetics of the supplement, secoisolariciresinol diglycoside.

General Pediatrics: Melatonin metabolism studies looking at shift work and effects on blood pressure in type 1 diabetes; suckling and PTHrP secretion and renal activity; bone mass tracking studies; bone density and forearm fractures in injured children.

Hematology: Sickle cell disease, including biotinylated erythrocyte studies and causes for thrombophilia.

Hepatology: Response of hepatitis C virus to pegylated interferon and ribavirin in hemophilic patients with/without coinfection with HIV.

Human Genetics: Phenotype and genetics of Gaucher's disease; enzyme therapy for Gaucher's disease; antiresorptive therapy for osteopenia in Gaucher's disease; bone densitometry in subjects with neurofibromatosis.

Infectious Disease: Indinavir/ritonavir therapy in HIV-affected subjects; efavirenz/nelfinavir pharmacokinetic study; pharmacokinetic interactions between HIV protease inhibitors and calcium channel blockers.

Neonatology: Hypothermia trial in term infants; parenteral glutamine supplementation in low-birthweight infants.

Nephrology: Renal tubular function in Bartter syndrome; immunosuppressive therapy after renal transplant in children; treatment of childhood nephrotic syndrome; urea kinetic modeling in hemodialysis patients; vascular abnormalities in children and adolescents with chronic renal disease; normalization of hematocrit in patients with chronic renal disease.

Psychiatry: Clomipramine treatment trials in depression and obsessive-compulsive disorder; fibromyalgia genetic studies.

Psychology: Behavioral nutrition studies involving weight gain in cystic fibrosis, feeding preterm infants, increasing dietary calcium in juvenile rheumatoid arthritis, and young children with chronic illness and their families; neuropsychological functioning in adolescents with spina bifida; Children's Health and Natural Growth Evaluation Study; depression and nutrition in pediatric sickle cell disease.

Pulmonary Medicine: Aerosolized tobramycin in young children with cystic fibrosis; dose cohort studies in cystic fibrosis subjects; effect of obstructive sleep apnea on cardiac function and structure in children.

Rheumatology: Calcium supplementation for bone mineralization in juvenile rheumatoid arthritis; genetic juvenile rheumatoid arthritis studies.

Contact Information

For information about this GCRC and how to access its resources, please contact:

Ohio State University

General Clinical Research Center
Ohio State University
Davis Medical Research Center
480 Medical Center Drive
Columbus, OH 43210-1228

Web Site: http://gcrc.osu.edu/

Grant No. M01 RR00034

Special Assays, Services, or Tests

Bionutrition and human performance laboratories: Basal or resting metabolic rate and substrate oxidation; metabolic kitchen services for feeding trials; feeding trial software (ProNutra); nutrient analysis software (Nutrition Data Systems for Research [NDS-R] and ESHA's Food Processor); food frequency questionnaires and analysis; body composition analysis with bioimpedance analysis or anthropometrics and DEXA for research fee; nutrition assessment, education, and counseling; max and sub-max exercise testing and physical activity assessment measurements and counseling; assistance with methods, protocol design, grant and paper development.

Core laboratory: RIA, enzyme immunoassay (EIA), chemiluminescence, HPLC with electrochemical detection, molecular PCR with AlphaImager2000; assay determinations include: C-peptide, IGF-I, DHEA sulfate, glucose, glucagon, insulin, sex-hormone binding, growth hormone, plasma and salivary cortisol, prolactin, ACTH, plasma catecholamines, homocysteine, calcitonin, gastrin, gastrin-releasing peptide, neurotensin, pancreastatin, pancreatic polypeptide, serotonin, substance P, vasoactive intestinal polypeptide

Informatics: Teleform data capture via scanning or faxing, research data mart, multicenter trial data management, computer lab Nursing services: Suction blister application for wound healing studies, chemotherapy administration, pharmacokinetic sampling, cardiac monitoring, hepatic glucose output studies, protocol-specific flowsheet design and development

Major Areas of Investigation

Behavioral Psychology: Smoking cessation.

Diabetes: Glucose regulation and insulin action; prevention trials of type 2 diabetes in African Americans; endocrine and metabolic responses after pancreatic transplant.

Exercise Physiology: Effect of exercise on glucose metabolism in type 2 diabetics; effect of exercise on reproductive hormones; effects of programs to change physical activity in various populations.

Health Psychology: Effect of stress on fatty-acid and homocysteine metabolism; effect of stress on immune, endocrine, and cardiovascular function in different populations of stressed individuals; stress and long-term survival in breast cancer patients; relaxation and wound healing studies.

Hematology and Oncology: Phase I and II clinical trials.

Infectious Diseases: AIDS Clinical Trials Group.

Nephrology: African Americans Study of Kidney Disease (AASK); progression of renal disease; factors in the progression of autosomal dominant polycystic kidney disease.

Neurology: Multiple sclerosis; Parkinson's disease.

Neuromuscular Diseases: Duchenne muscular dystrophy; amyotrophic lateral sclerosis; gene therapy; limb girdle muscular dystrophy (LGMD).

Nutrition: Metabolic studies; soy and/or lycopene studies; gestational and type 2 diabetes studies.

Psychiatry: Drug effects in autism.

Pulmonary Medicine: Emphysma lung reduction study; HIV-induced emphysema, mechanisms of lung injury.

Women's Health: Risks and benefits of a number of treatments that may improve the health of postmenopausal women.

Contact Information

For information about this GCRC and how to access its resources, please contact: