North Carolina

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University of North Carolina (Chapel Hill)
Wake Forest University School of Medicine (Winston-Salem)

University of North Carolina

General Clinical Research Center
Memorial Hospital, Campus Box #7600
University of North Carolina School of Medicine
Chapel Hill, NC 27599-7600

Web site: http://verne.med.unc.edu external link, opens in new window

Grant No. M01 RR00046

Special Assays, Services, or Tests

Detailed dietary analysis (calories, protein, carbohydrates, fats, Na, K, Ca, PO4), choline, d-chiro inositol
ELISA core lab
Plasma and urine catecholamines

Special Resources, Instruments, or Services

Body composition laboratory–DEXA, indirect calorimeter, bioelectrical impedance analysis (BIA), anthropometrics
HPLC
HPLC electrospray mass spectrometer
Human applications laboratory
Pulmonary function lab for children and adults
Treadmill exercise EKG, metabolic monitoring

Major Areas of Investigation

Cardiology: Noninvasive evaluation of cardioactive drugs; neurohumoral factors in heart failure; therapy of hypercholesterolemia.

Cystic Fibrosis: Development and testing of novel therapeutic approaches, including aerosolized amiloride and adenine nucleotides; gene therapy; role of atypical mycobacterial infection.

Dentistry: Role of oral inflammation in systemic diseases.

Dermatology: Pathogenesis of epidermolysis bullosa, bullous pemphigoid, and other bullous skin diseases.

Endocrinology: Growth hormone and insulin-like growth factors (IGF) in pituitary disorders; nutritional regulation of IGF and IGF-binding protein production; growth hormone therapy of short but GH-sufficient children; use of GH in obese subjects; diagnostic test evaluation in Cushing's syndrome; regulation of TSH secretion; GH and IGF-I in HIV.

Gastroenterology: Therapy of inflammatory bowel disease; localization of intestinal sites of drug absorption; case-control study of colonic tumor patients; hepatitis B and C therapy; Norwalk virus challenge; drug-induced liver disease.

Gynecology: Molecular predictors of natural history of uterine fibroids; gynecologic oncology group treatment protocols for cancer of the ovary, uterus, and fallopian tubes.

Hematology and Oncology: Gene therapy for hemophilia; novel therapies for sickle cell anemia; proteosome inhibitors in the treatment of hematological and solid malignancies; molecular predictors of tumor response to treatments; adoptive immunotherapy of malignancies.

HIV and AIDS: Treatment for HIV-1 infection with antiretroviral compounds and immune modulators including IL-2 and thalidomide; treatment for AIDS-related opportunistic infections including Pneumocystis carinii pneumonia, Mycobacterium-avium intracellulare, aphthous ulcers, particularly cytomegalovirus infections and cryptococcal infections; therapy of HIV-1 including treatment with protease inhibitors and nonnucleoside compounds; treatment of membrane attack complex, resistant herpes simplex virus infections, and cryptococcal meningitis; treatment of pediatric HIV-1 infection and AIDS, including therapeutic protocols and other nucleoside analogues; evaluation of therapies to prevent HIV-1 transmission from seropositive pregnant women to their infants; treatment of HIV-1-related malignancies; neurologic consequences of HIV-1 infection; psychiatric and social impact of HIV-1 infection and of HIV-1 high-risk behavior, especially in men who have sex with men; pharmacokinetic studies of medications used in treatment of HIV and HIV-related opportunistic infections.

Infectious Diseases: Hepatitis infection in hemophiliacs; sexually transmitted diseases, including studies in gonorrheal pathogenesis and vaccine development; antifungal therapy in the immunocompromised host.

Neurology: Sensory-evoked potential changes in nervous system dysfunction and anticonvulsant drug withdrawal; evaluation of new anticonvulsant drugs; evaluation of CNS function in HIV-positive patients.

Pharmacology: Molecular determinants of drug disposition; use of probe drugs to determine drug metabolism enzyme/transporter phenotype.

Psychiatry: Neurohumoral effects of chlorimipramine and oxytocin; antidepressant drug effects in noradrenergic and serotoninergic systems; renal and cardiovascular effects of psychological stress; coping in patients with HIV infection; postpartum depression; coping in sickle cell disease.

Pulmonary Disorders: Pathophysiology of reactive airways disease; treatment of asthma.

Surgery: Chemotherapy of brain tumor following surgery; active immunotherapy for anaplastic gliomas.

Women's Health: Hormone replacement therapy; dietary modification; calcium and vitamin D supplementation; factors involved in preterm birth.

Contact Information

For information about this GCRC and how to access its resources, please contact:

Administrative Director
Mary Beth Lister, M.P.H.
919-966-4767; Fax: 919-966-1576
E-mail: mblister@med.unc.edu

Program Director
Paul B. Watkins, M.D.
919-966-1435; Fax: 919-966-1576
E-mail: pbwatkins@med.unc.edu

Principal Investigator
Eugene P. Orringer, M.D.
919-966-4161; Fax: 919-966-7564
E-mail: epo@med.unc.edu

Associate Program Director
Michael Fried, M.D.
919-966-2516; Fax: 919-966-1700
E-mail: mfried@med.unc.edu

Associate Program Director
Joseph J. Eron, Jr., M.D.
919-966-2536; Fax: 919-966-6714
E-mail: jeron@med.unc.edu

Associate Program Director (Dentistry)
James Beck, Ph.D.
919-966-2787; Fax: 919-966-6761
E-mail: jim_beck@dentistry.unc.edu

Core Laboratory Director
Gary Pollack, Ph.D.
919-966-9989; Fax: 919-966-9650
E-mail: gary_pollack@unc.edu

Research Subject Advocate, Epidemiologist
David J. Weber, M.D., M.P.H.
919-966-2536; Fax: 919-966-1576
E-mail: DWeber@unch.unc.edu

Research Subject Advocate
Marie Zeldin, R.N., B.S.N.
919-966-6844; Fax: 919-966-1576
E-mail: mzeldin@med.unc.edu

GCRC Advisory Committee Chairperson
Ralph Raasch, Pharm.D.
919-962-0071; Fax: 919-962-0644
E-mail: ralph_raasch@unc.edu

Nurse Manager
Nancy Cozart, M.P.A., R.N.
919-966-4744; Fax: 919-966-1576
E-mail: ncozart@med.unc.edu

Training and Career Development
Susan Pusek, M.P.A.
919-966-0128; Fax: 919-966-1576
E-mail: suspusek@med.unc.edu

Nutrition Research Manager
Marjorie Busby, M.P.H., R.D.
919-966-4746; Fax: 919-966-1576
E-mail: mgbusb@med.unc.edu

Biostatistician
Paul W. Stewart, Ph.D.
919-966-7276; Fax: 919-966-3804
E-mail: paul_stewart@unc.edu

Computer Systems Manager
Clarence Potter, M.S.
919-966-4802; Fax: 919-966-1576
E-mail: cpotter@med.unc.edu

Wake Forest University School of Medicine

General Clinical Research Center
Wake Forest University School of Medicine
Medical Center Boulevard
Winston-Salem, NC 27157

Web site: www.gcrc.wfubmc.edu external link, opens in new window

Grant No. M01 RR07122

Special Resources, Instruments, or Services

Ankle and brachial blood pressure indices
Anthropometry
Bronchoscopy
Chemotherapy
Clinical breast exams
Cognitive testing
Computerized diet planning for balanced, constant and weighed diets
Conscious sedation

Food frequency administration and analysis
Geriatric GCRC
Hewlett-Packard monitor for blood pressure, respiration, pulse oximetry and cardiac rhythms
Intravenous and oral glucose tolerance testing
Metabolic research kitchen
Nutrition data system for research
Nutrition education
Stress testing

Major Areas of Investigation

Anesthesiology: New spinal anesthetic agents for childbirth and chronic pain.

Cardiovascular Diseases: Treatments for peripheral arterial disease; hypertension and salt sensitivity; exercise training and congestive heart failure; multiethnic study of atherosclerosis; ACE inhibition and novel cardiovascular risk factors; diastolic heart failure.

Dermatology: Psoriasis; reinforcing properties of UV light in tanning bed users.

Endocrinology: Diabetes prevention trial; inhaled insulin versus subcutaneous insulin therapy in diabetes; LDL cholesterol-lowering drugs in hypercholesterolemia.

Gastroenterology: Responses to dietary fat and cholesterol; oxalate studies; virtual colonoscopy.

Genetics: Genetic epidemiology of diabetic cardiovascular disease; molecular epidemiology of breast cancer and prostate cancer; genes and chronic obstructive pulmonary disease; genetics of bone in type 2 diabetes.

Geriatrics and Gerontology: Arthritis, diet, and activity promotion; depression in the elderly; resistance training in older adults; diet, exercise, and metabolism in older women.

Hematology and Oncology: Prostate cancer prevention; diphtheria fusion toxin therapy of myeloid leukemia; recovery in breast cancer; chemotherapy-induced cardiomyopathy and MRI.

Infectious Diseases: Cellular mechanisms of septic shock.

Nephrology: Hemodialysis and quality of life; progression of renovascular disease in the elderly.

Neurology: Treatment of chronic inflammatory demyelinating polyneuropathy; amyotrophic lateral sclerosis; Huntington's disease.

Obstetrics and Gynecology: Ovarian cancer screening study; fatty acids and preterm birth; folic acid load in pregnant epileptic women.

Pediatrics: Ventilation in very-low-birthweight infants; cystic fibrosis, sinusitis; bone strength in children; effect of postnatal dexamethasone on children at school age.

Physiology and Pharmacology: Regional brain activation during cocaine abstinence.

Psychiatry: Optimization of electroconvulsive therapy for depression.

Pulmonary Diseases: Lipid pathways and lung injury; asthma studies; lung cancer screening.

Rheumatology: Systemic lupus erythematosus; T cells.

Urology: Role of oxalate in nephrolithiasis.

Women's Health: Women's Health Initiative (WHI); WHI memory study (WHIMS).

Contact Information

For information about this GCRC and how to access its resources, please contact:

Administrative Director
Marcy Poletti, R.N., M.S.N.
336-716-9755; Fax: 336-716-5055
E-mail: mpoletti@wfubmc.edu

Program Director
Charles E. McCall, M.D.
336-716-4584; Fax: 336-716-3825
E-mail: chmcall@wfubmc.edu

Principal Investigator
William B. Applegate, M.D.
336-716-3430; Fax: 336-716-5139
E-mail: wapplega@wfubmc.edu

Associate Program Director
John R. Crouse III, M.D.
336-716-2076; Fax: 336-716-6164
E-mail: jrcrouse@wfubmc.edu

Associate Program Director
Richard B. Weinberg, M.D.
336-716-4638; Fax: 336-716-6376
E-mail: weinberg@wfubmc.edu

Associate Program Director
Jeff D. Williamson, M.D.
336-713-8583; Fax: 336-713-8800
E-mail: jwilliam@wfubmc.edu

Research Subject Advocate
Susan Margitic, M.S.
336-716-5647; Fax: 336-716-0395
E-mail: smargitic@wfubmc.edu

GCRC Advisory Committee Chairperson
R. Duncan Hite, M.D.
336-716-9442; Fax: 336-716-7277
E-mail: dhite@wfubmc.edu

Research Nurse Manager
Marcy Poletti, R.N., M.S.N.
336-716-9755; Fax: 336-716-5055
E-mail: mpoletti@wfubmc.edu

Bionutrition Research Manager
Linda Easter, R.D., M.S., L.D.N.
336-716-6355; Fax: 336-716-5055
E-mail: leaster@wfubmc.edu

Processing Lab Manager
Marcia Burris
336-716-2676; Fax: 336-716-5055
E-mail: mburris@wfubmc.edu

Molecular Genetics Core Director
Donald W. Bowden, Ph.D.
336-713-7507; Fax: 336-716-5055
E-mail: dbowden@wfubmc.edu

Biostatistician
Timothy Morgan, Ph.D.
336-713-3829; Fax: 336-713-3806
E-mail: tomorgan@wfubmc.edu

Informatics Core Manager
Robert Amoroso
336-716-7786; Fax: 336-716-5055
E-mail: bamoroso@wfubmc.edu