Indiana University

General Clinical Research Center
University Hospital, Room 5595
Indiana University School of Medicine
550 North University Boulevard
Indianapolis, IN 46202-5250

Web site: www.gcrc.iupui.edu/default.htm

Grant No. M01 RR00750

Special Assays, Services, or Tests

Special Resources, Instruments, or Services

Major Areas of Investigation

AIDS: Drug therapy in the management of patients with AIDS and its complications.

Alcohol Studies: Alcohol utilization and elimination rates determined by alcohol clamping; twin and family studies on the acute effects of alcohol.

Amyloidosis: Presentation and prognosis of human amyloidosis.

Bone Diseases: : Genetics of bone strength in men and of bone loss in women; genetic determinants of peak bone mass in women; clinical and genetic analysis of autosomal dominant hypophosphatemic rickets; clinical and genetic studies of autosomal dominant osteopetrosis; bisphos-phonate therapy for osteogenesis imperfecta and childhood osteoporosis; effects of bisphosphonates, PTH on postmenopausal osteoporosis; effects of calcimimetic agents in primary hyperparathyroidism; effect of isoflavones on calcium metabolism in humans; calcium requirements in adolescence.

Cancer: Drug treatment of cancers including breast, pancreatic, colorectal, lung and osteosarcoma.

Cardiology: Cardiac, neural, and conduction dysfunction in myotonic dystrophy.

Diabetes: Insulin resistance; endothelial function; obesity gene; early diabetes intervention program; diabetes prevention trial in type 1 diabetes; HIV-related proteinuria and endothelial dysfunction; HIV-1 protease inhibitors' effect on endothelial function and glucose metabolism in normal, HIV-uninfected subjects; early diabetes prevention program; subcutaneous insulin infusion versus insulin injection therapy in very young children with type 1; diabetes prevention trial type 1 (pediatrics); prevention of diabetes progression trial.

Gene Therapy: Treatment of germ cell tumors, chronic myelogenous leukemia, multiple myeloma, non-Hodgkin's lymphoma, poor prognosis pediatric and adult brain tumors, x-linked chronic granulomatous disease.

Genetics: Cardiovascular disease risk factors and brain morphology in twins; pilot Huntington's disease (HD) at-risk observational study; longitudinal studies among at-risk HD gene carriers; identification of the gene causing spheroid body myopathy. Hypertension: Longitudinal study of blood pressure regulation in young people; the relation of race to renal hemodynamics; ascertainment of hypertensive patients for genetic studies; salt sensitivity; cardiovascular metabolic bone disease.

Infectious Diseases: Experimental human infection with Hemophilus ducreyi.

Neonatology: Protein and carbohydrate metabolism and regulation in newborns; glutamine supplementation for extremely low birthweight infants; mechanically evoked reflexes and functional oromotor skill acquisition in preterm infants; energy requirements and expenditure in healthy and ill newborns; neonatal inhaled nitric oxide study.

Neurology: Treatment of Huntington's disease; treatment of Alzheimer's disease.

Pharmacology: Drug interactions in renal clearance; the role of CYP3A on drug metabolism; effect of chloroquine on opiate receptors; profiling Tamoxifen with pharmacogenetic predictors.

Psychiatry: Medical treatment of autistic disorders, schizophrenia, mood disorders; treatment of hyperactivity and impulsiveness in pediatrics with pervasive developmental disorders.

Transplantation: Medical treatment of rejection in renal transplant patients; assessment of anitphiX174 antibody response in previously treated dialysis patient.

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