Illinois

Northwestern University

General Clinical Research Center
Feinberg Pavilion, Suite 10-760B
Northwestern Memorial Hospital
251 East Huron Street
Chicago, IL 60611
GCRC: www.feinberg.northwestern.edu/gcrc
Informatics Core: www.gcrc.northwestern.edu/ic

GCRC: www.feinberg.northwestern.edu/gcrc

Informatics Core: www.gcrc.northwestern.edu/ic

Grant No. M01 RR000489

Special Assays, Services, or Tests

C-peptide
D-xylose
Inulin
Leptin
Melatonin
Vasopressin

Special Resources, Instruments, or Services

Body composition analyzer, single and multifrequency
Cardiac monitoring and telemetry
Metabolic cart for basal energy expenditure measurement
Polysomnograph recording

Major Areas of Investigation

Bone Marrow Transplantation: Bone marrow transplantation as therapy for autoimmune disease: multiple sclerosis, rheumatoid arthritis, Crohn's disease, scleroderma, and systemic lupus erythematosus.

Cardiovascular Diseases: Antiarrhythmic therapy; therapy of congestive heart failure; functional assessment; cardiac arrhythmias; circadian and gender variation in electrical activity of the heart; cardiac memory and diastolic function; peripheral arterial disease; parasympathetic tone during exercise.

Endocrinology and Metabolism: Hyperglycemia and pregnancy outcome; acanthosis nigricans and risk factors for type 2 diabetes (adolescents); islet cell transplantation; phenotype and genotype in familial polycystic ovary syndrome; pathogenesis of familial diabetes insipidus; treatment of hyponatremia with a vasopressin antagonist; hormonal function in pituitary hypothalamic disease; prevention of diabetes mellitus; vasopressin function in nocturnal enuresis (adults and children); desmopressin regulation effects on salt and water balance; growth disorders.

Gastroenterology: Antiviral treatment strategies in hepatitis C; D-xylose kinetics in malabsorption; malabsorption in intestinal transplantation; abnormal circadian rhythms in cirrhosis; short bowel syndrome; ulcerative colitis.

Infectious Diseases: AIDS and AIDS-related complex in adults and children; fat maldistribution and metabolic changes in HIV-infected patients.

Nephrology: Effects of renal disease on the pharmacokinetics of drugs; dopaminergic regulation of aldosterone secretion; effects of potassium balance on antidiuretic function; racial differences in sodium and potassium metabolism.

Neurology: Alzheimer's disease; treatment of aphasia and spatial neglect; effects of light and exercise on circadian rhythms; effects of sleep on auditory and perceptual learning; genetic studies of aneurysmal subarachnoid hemorrhage.

Oncology: Radiolabeled monoclonal antibodies in treatment of cutaneous T cell lymphoma and adenocarcinoma of the lung; monoclonal antibodies for radioimmunodetection and radioimmunoassay; monoclonal antibody therapy; use of plasminogen activator therapy for antiangiogenic therapy; chemopreventive agents.

Pediatrics: Vasculitis and connective tissue disease; type 2 diabetes in pediatric patients; HIV; partial external biliary diversion for chronic cholestasis in Alagille syndrome; nutritional status and liver function in children with biliary atresia; corticotropin-releasing factor in cyclic vomiting; cystic fibrosis.

Pulmonary Medicine: Pseudomonas aeruginosa infection in cystic fibrosis; ion transporters in bronchial epithelial cells in asthma; sleep apnea severity and simulated driving performance; chronic obstructive pulmonary disease.

Rheumatology: Systemic lupus erythematosus; osteoarthritis treatment; osteoporosis; neuromechanical factors in the progression of knee osteoarthritis.

Transplantation: Pancreas, bone marrow, intestinal, and islet cell transplantation.

Women's Health: Estradiol levels in the breast; estrogen exposure from oral contraceptives; milk availability and lactation status.

Contact Information

For information about this GCRC and how to access its resources, please contact: