Colorado

ON THIS PAGE:

University of Colorado–Adults (Denver)
National Jewish Medical and Research Center (Denver)
University of Colorado at Boulder, Wardenburg Health Center (Boulder)
University of Colorado–Children (Denver)

University of Colorado–Adults

General Clinical Research Center
University of Colorado Health Sciences Center
4200 East 9th Avenue, B141
Denver, CO 80262

Web site: http://gcrc.uchsc.edu external link, opens in new window

Grant No. M01 RR00051

Center Resources

Adiponectin
Aldosterone
Angiotensin II
Arginine vasopressin
Atrial natriuretic peptide
Beta-hydroxybutyrate
Cholesterol
C-peptide
Creatinine (serum/plasma, urine)
DHEA
DHEAS
Endothelin I
Epinephrine–HPLC
Estradiol, estradiol-us
Estrone
Follicle-stimulating hormone
Free fatty acids
Galactose
Glucagon
Glucose
Glycerol
High-density lipoprotein total (direct), HDL-C subfraction 3 (precipitation),

HDL-C total (precipitation)
IGF-I
IGF-BP3 (binding protein-3)
IL-6
Insulin
Ketones (urine)
Lactate
Leptin
Lipid fractionation by fast protein liquid chromatography (FPLC)
Luteinizing hormone
Norepinephrine– HPLC (urinary)
Oxidized low-density lipoprotein
Progesterone
Reduced glutathione
Renin
Sex-hormone-binding globulin
Superoxide dismutase (SOD-1)
Total antioxidate status (TAS)
Thiobarbituric acid reactive substances (TBARS)
Triglycerides

Major Areas of Investigation

Cardiology: Congestive heart failure.

Clinical Pharmacology: Aging; blood pressure regulation.

Endocrinology: Thyroid hormone action.

Gastroenterology: Bile acid metabolism.

Immunology: AIDS.

Metabolism and Nutrition: Obesity; diabetes mellitus; energy balance; exercise; micronutrients; electrolytes in food (flame photometry).

Nephrology: Edematous diseases; polycystic kidney disease; hypertension.

Oncology: Biological modifiers; cancer screening; malignant melanoma; CNS tumors.

Psychiatry: Schizophrenia, drug action; stress; alcoholism.

Pulmonary Diseases: Primary pulmonary hypertension.

Contact Information

For information about this GCRC and how to access its resources, please contact:

Administrative Manager
Tim Lockie, M.S., M.B.A.
303-372-8801; Fax: 303-372-5866
E-mail: tim.lockie@uchsc.edu

Program Director
Robert H. Eckel, M.D.
303-724-3923; Fax: 303-724-3924
E-mail: robert.eckel@uchsc.edu

Principal Investigator
Richard D. Krugman, M.D.
303-315-7565; Fax: 303-315-8494
E-mail: richard.krugman@uchsc.edu

Associate Program Director
Thomas B. Campbell, M.D.
303-315-8311; Fax: 303-724-8601
E-mail: thomas.campbell@uchsc.edu

Associate Program Director
Bryan Haugen, M.D.
303-315-3486; Fax: 303-315-4525
E-mail: bryan.haugen@uchsc.edu

Research Subject Advocate
Alison Lakin, R.N., L.L.B., L.L.M., Ph.D.
303-372-8810; Fax: 303-372-5866
E-mail: alison.lakin@uchsc.edu

Research Subject Advocate
David Badesch, M.D.
303-315-1805; Fax: 303-315-1806
E-mail: david.badesch@uchsc.edu

GCRC Advisory Committee Chairperson
Robert H. Eckel, M.D.
303-315-8443; Fax: 303-372-5866
E-mail: robert.eckel@uchsc.edu

Nurse Manager
Barbara DiMercurio, R.N., B.S.
303-372-8814; Fax: 303-372-8819
E-mail: barbara.dimercurio@uchsc.edu

Core Laboratory Director
Maureen Garrity, Ph.D.
303-372-8798; Fax: 303-372-5866
E-mail: maureen.garrity@uchsc.edu

Bionutrition Research Manager
Coni Francis, Ph.D., R.D.
303-372-8838; Fax: 303-372-5866
E-mail: coni.francis@uchsc.edu

Biostatistician
John Kittelson, Ph.D.
303-315-5279; Fax: 303-315-3183
E-mail: john.kittelson@uchsc.edu

Informatics Manager
Thomas Yaeger, B.S.
303-372-8803; Fax: 303-372-5866
E-mail: thomas.yaeger@uchsc.edu

University of Colorado

General Clinical Research Center Satellite
National Jewish Medical and Research Center, Room K-341
1400 Jackson Street
Denver, CO 80206

Grant No. M01 RR00051

Special Assays, Services, or Tests

Cytokine analysis
Inflammation markers
Psychosocial assessment
T cell phenotyping
T cell receptor gene usage

Major Areas of Investigation

Allergy: Food allergy; respiratory allergy.

Dermatology: Atopic dermatitis; psoriasis.

Genetic Diseases: Atopic gene-linkage abnormalities.

Infectious Diseases: Tuberculosis; mycoplasma.

Occupational Medicine: Beryllium toxicity; air pollution.

Pharmacology: Pharmacokinetics of asthma and tuberculosis drugs.

Psychiatry: Adherence; outcome studies.

Pulmonary Disease: Asthma; interstitial lung disease; pulmonary fibrosis; sarcoidosis; berylliosis; inflammatory mediators.

Contact Information

For information about this satellite and how to access its resources, please contact:

Program Administrator
Pat Kittelson
303-398-1717; Fax: 303-270-2207
E-mail: kittelsonp@njc.org

Associate Program Director
Donald Y. M. Leung, M.D.
303-398-1186; Fax: 303-270-2182
E-mail: leungd@njc.org

Research Subject Advocate
Henry Milgrom, M.D.
303-398-1999
E-mail: milgromh@njc.org

GCRC Advisory Committee Chairperson
Robert H. Eckel, M.D.
303-315-8443; Fax: 303-372-5866
E-mail: robert.eckel@uchsc.edu

Nurse Manager
Trudi Madigan, R.N.
303-398-1434; Fax: 303-270-2207
E-mail: madigant@njc.org

Core Laboratory III Director
Lee Newman, M.D., M.S.
303-398-1983; Fax: 303-398-1452
E-mail: newmanl@njc.org

Core Laboratory IV Director
Frederick Wamboldt, M.D.
303-398-1135; Fax: 303-270-2115
E-mail: wamboldtf@njc.org

Biostatistician
James Murphy, Ph.D.
303-398-1686; Fax: 303-270-2131
E-mail: murphyj@njc.org

University of Colorado–Adults

General Clinical Research Center Satellite
Wardenburg Health Center, Room 376
University of Colorado
18th Street & Wardenburg Drive
Boulder, CO 80309-0119

Grant No. MO1 RR00051

Special Assays, Services, or Tests

Baroreflex responsiveness
DEXA scans
Exercise prescriptions, monitoring and compliance
Muscle sympathetic nerve activity
Pulse wave velocity and applanation tonometry
Resting and exercise oxygen consumption
Whole-limb blood flow
Cardiac output during exercise

Major Areas of Investigation

Aging: Endothelial function; autonomic nervous system; steadiness training.

Alcohol Addiction: Pharmacological mechanisms.

Cardiovascular Physiology: Vascular endothelial biology; large artery compliance.

Exercise Intervention: Hypertension; aging.

Immunology: Physical activity and immune function.

Skeletal Muscle Physiology: Exercise-induced muscle injury; muscle fatigue of motor steadiness.

Contact Information

For information about this satellite and how to access its resources, please contact:

Assistant Administrative Manager
Emily Edwards, M.S.
303-735-2521; Fax: 303-735-1968
E-mail: emily.baker@colorado.edu

Assistant Program Director
Douglas R. Seals, Ph.D.
303-492-5305; Fax: 303-492-6778
E-mail: seals@spot.colorado.edu

Research Subject Advocate
William Byrnes, Ph.D.
303-492-5301; Fax: 303-492-6778
E-mail: william.byrnes@colorado.edu

GCRC Advisory Committee Chairperson
Robert H. Eckel, M.D.
303-315-8443; Fax: 303-372-5866
E-mail: robert.eckel@uchsc.edu

Core Laboratory Director
Robert Mazzeo, Ph.D.
303-492-1509; Fax: 303-492-6778
E-mail: robert.mazzeo@colorado.edu

Bionutritionist
Kathleen Farrell, M.S.
303-735-2125; Fax: 303-735-1968
E-mail: kathleen.farrell@spot.colorado.edu

Biostatistician
Gregory Carey, Ph.D.
303-492-1658; Fax: 303-492-2967
E-mail: gregory.carey@colorado.edu

University of Colorado–Children

General Clinical Research Center
Children's Hospital, B218
1056 East 19th Avenue
Denver, CO 80218

Web site: www.uchsc.edu/pedsgcrc external link, opens in new window

Grant No. M01 RR00069

Special Assays, Services, or Tests

Adrenocorticotropic hormone
Alpha-1-antitrypsin
Anti-Pseudomonas aeruginosa
Bile acids, total
Bone-specific alkaline phosphatase
Bromide
C-reactive protein, high sensitivity
Caffeine (serum and saliva)
Calcitonin
Carbohydrate antigen 19-9 (CA 19-9)
Carotene, alpha and beta
Carotenoids (micro): beta cryptoxanthin; lutein/zeaxanthin; lycopene, total
Coenzyme Q-10
Cortisol (urine and saliva)
Cyclic guanosine monophosphate (c-GMP)
DNA total
2,3 Diphosphoglyceric acid (DPG)
Deoxypyridinoline crosslinks
Elastase free; elastase, polymorphonuclear (PMN)
Endothelin-1
Eosinophil cationic protein (ECP)
E-selectin
Galactose
Glutathione peroxidase; glutathione reductase
Granulocyte colony stimulating factor (GCSF)
Granulocyte macrophage colony stimulating factor (GM-CSF)
Immunoglobulin-A (IgA)
Immunoreactive trypsinogen (IRT)
Insulin-like growth factor 1 (IGF-I/somatomedin C)
Insulin-like growth factor binding protein 3 (IGFBP-3)

Interferon Gamma (IFN-gamma)
Interleukin-1 alpha and beta; -1ra; -2; -3; -6; -6 receptor; -8; -10; -11; -12
Intracellular adhesion molecule (ICAM)
Lactoferrin
Lactulose
Lipids, total
Lysozyme
Mannitol
Microalbumin
Micro total protein
Myeloperoxidase
N-telopeptide
Nitrite and nitrate
Nitrogen
Osteocalcin
Pancreatic elastase-1 (fecal)
Parathyroid hormone (PTH) N-tact
Pit count, red cell
Polyethylene glycol
Prealbumin
Procollagen type I and II
Pyridinium crosslinks
Retinol-binding protein
Retinyl palmitate
Secretory leukocyte protease inhibitor (SLPI)
Transforming growth factor beta (TGF-beta)
Tumor necrosis factor, alpha and beta (TNF-alpha, -beta) Urea, bronchoalveolar lavage (BAL) and urine
Vascular endothelial growth factor (VEGF)
Vitamin A (retinol)
Vitamin D, 25-hydroxy
Vitamin E (alpha and gamma tocopherol)

Special Resources,Instruments, or Services

DEXA
Indirect calorimetry
Specialized anthropometric equipment
Specialized neonatal equipment

Major Areas of Investigation

Diabetes and Endocrinology: Prediabetes and autoimmunity; prevention of type 1 diabetes; genetics of type 1 diabetes; treatment of type 2 diabetes; polycystic ovary syndrome.

Gastroenterology and Hepatology: Celiac disease; biliary atresia; childhood cirrhosis; alpha-1 antitrypsin deficiency; liver disease in cystic fibrosis; nonalcoholic steatohepatitis; short bowel syndrome.

Genetics and Metabolism: Inborn errors of metabolism; congenital hypothyroidism.

Hematology: Hemophilia joint disease; congenital thrombotic disease; sickle cell disease.

Immunology: Childhood vaccine immunology.

Infectious Diseases: HIV; sexually transmitted diseases; respiratory syncytial virus; childhood vaccine development.

Neonatology: Nitric oxide and steroid therapy to prevent bronchopulmonary dysplasia; nutrition in growth-restricted neonates; glucose metabolism in low-birthweight infants; amino acid and protein metabolism; neonatal infection.

Nephrology: Polycystic kidney disease; hyperlipidemia in chronic renal disease.

Neurocognitive Development: Autism; sensory integration disorders; effects of intrauterine nicotine exposure; adolescent psychosis.

Neurology and Rehabilitation Medicine: Muscular dystrophy; spina bifida; neurotrauma.

Nutrition: Childhood obesity; energy metabolism; trace metal metabolism; nutrition in the premature infant; cystic fibrosis; liver disease; osteoporosis in pediatric diseases.

Oncology: Sarcomas; CNS tumors.

Pulmonary Medicine: Early detection and therapy of cystic fibrosis (CF); genomics of airway epithelium in CF; aminoglycoside treatment in CF; nitric oxide therapy in CF; gene therapy in CF.

Contact Information

For information about this GCRC and how to access its resources, please contact:

Administrative Manager
Puff Stevens
303-837-2957; Fax: 303-764-8407
E-mail: stevens.puff@tchden.org

Program Director
Ronald J. Sokol, M.D.
303-861-6669; Fax: 303-764-8407
E-mail: sokol.ronald@tchden.org

Principal Investigator
Richard D. Krugman, M.D.
303-315-7565; Fax: 303-315-8494
E-mail: richard.krugman@uchsc.edu

Associate Program Director
William W. Hay, Jr. M.D.
303-724-1600; Fax: 303-724-0898
E-mail: bill.hay@uchsc.edu

Associate Program Director
Philip S. Zeitler, M.D., Ph.D.
303-861-6128; Fax: 303-864-5670
E-mail: zeitler.philip@tchden.org

Assistant Program Director
Nancy Krebs, M.D.
303-315-5304; Fax: 303-315-3273
E-mail: nancy.krebs@uchsc.edu

Research Subject Advocate
Theresa A. O'Lonergan, M.A.
303-764-8538; Fax: 303-764-8407
E-mail: o'lonergan.theresa@tchden.org

GCRC Advisory Committee Co-Chairperson
Paul Fennessey, Ph.D.
303-315-7286; Fax: 303-315-0080
E-mail: paul.fennessey@uchsc.edu

GCRC Advisory Committee Co-Chairperson
Rachelle Nuss, M.D.
303-861-6776; Fax: 303-837-2831
E-mail: nuss.rachelle@tchden.org

Nurse Manager
Diane L. Branham, R.N., B.S.N.
303-869-3195; Fax: 303-764-8125
E-mail: branham.diane@tchden.org

Core Laboratory Medical Director
Frank J. Accurso, M.D.
303-837-2522; Fax: 303-764-8159
E-mail: accurso.frank@tchden.org

Core Lab Technical Director
Iris Osberg, M.T.
303-764-8205; Fax:303-764-8159
E-mail: osberg.iris@tchden.org

Nutrition Research
Janine Higgins, Ph.D.
303-837-2955; Fax: 303-764-8187
E-mail: higgins.janine@tchden.org

Biostatistician
Jane Gralla, Ph.D.
303-837-3895; Fax: 303-764-8407
E-mail: gralla.jane@tchden.org

Informatics Core
Bob DiLaura, D.B.A., M.B.A.
303-764-8373; Fax: 303-764-8407
E-mail: dilaura.bob@tchden.org