Alabama

University of Alabama at Birmingham

General Clinical Research Center, Room M 907
University of Alabama at Birmingham
625 South 19th Street
Birmingham, AL 35233-6909

Web site: http://www.gcrc.uab.edu

Grant No. M01 RR00032

Special Resources, Instruments, or Services

Anthropometrics and dietary counseling
Computerized nutrient analysis with Minnesota Nutrition Data System for Research
DNA immortalization
–70° Freezer
Glucose clamp technology
Infusion facilities
Intravenous glucose tolerance testing
Laminar flow hood
Metabolic research kitchen, metabolic diet planning, outpatient and inpatient feeding
Molecular genetics core
Negative airflow isolation rooms
Physiology and metabolism core
SensorMedics Deltatracs
Specimen processing facility
Teleform preparation and management

Training Opportunities

Clinical investigator fellowship award
Nutrition fellowships for nutrition Ph.D. students
Nutrition traineeships for nutrition master's degree students

Major Areas of Investigation

AIDS: NMR imaging for effects of protease inhibitors on intramuscular lipids in HIV and cognitive/motor complex; nutrition and physical activity in HIV; AIDS Clinical Trial Group phase I and II studies.

Cardiology: Effect of dietary lipids on chylomicrons; bypass angioplasty revascularization investigation in type 2 diabetes study; identification of polymorphisms associated with low levels of plasma HDL; nitric oxide and cardiovascular reactivity; congestive heart failure and exercise training; low-glycemic diet in hypercholesterolemia.

Endocrinology: Adrenal androgen excess in hyperandrogenic oligo-ovulation; metabolic response to variations in dietary composition; insulin resistance, dietary cholesterol, and cholesterol concentration; impact of dietary fat hyperandrogenism and ethnic differences in insulin sensitivity; phosphorylation of insulin receptor in skin and adipose tissue; diabetes mellitus in polycystic ovary syndrome; obesity treatment in non-insulin-dependent diabetes mellitus.

Geriatric Medicine: Genetic and environmental factors in immunity in aging; primary care patient services; muscle plasticity with resistance training in older adults.

Hematology: Sickle cell disease; hemochromatosis; phase I/II pharmacokinetics in liver transplant recipients.

Immunology: Biological definition of host defense defects.

Infectious Diseases: Perinatal infections, symptomatic congenital cytomegalovirus (CMV) infections; neonatal herpes simplex infections; invasive fungal infections; treatment of neonates with enteroviral sepsis syndrome; vaccine trial for CMV infection; antiviral treatment for hearing loss in CMV infection; herpes simplex encephalitis and valacyclovir.

Nephrology: Osteonecrosis in renal transplants; loss of kidney function in sickle cell disease, polycystic kidney disease; genetic polymorphisms in Wegener's granulomatosis; familial IgA nephropathy; allograft nephropathy in pediatric renal transplant.

Nutrition: Energy expenditure in post-obese black and white women; intra-abdominal fat and risk of disease in children and adolescents; energy expenditure and body composition in pubescent females; exercise training in obesity; weight management among spinal-cord-injured population; eating behavior in homebound older adults; energy metabolism and body composition in spinal cord disorder.

Oncology: Prostate cancer; non-small-cell lung cancer; T cell malignancies; brain tumors; ovarian cancer; B cell lymphoma; metastatic breast cancer; advanced carcinoma; colorectal cancer; advanced squamous cell carcinoma of the head and neck; metastatic carcinoembryonic antigen (CEA)-expressing adenocarcinoma; malignant mesothelioma; surgically incurable melanoma; solid tumors; non-Hodgkin's lymphoma; Hodgkin's disease; astrocytoma; glioblastoma multiforme; AIDS-associated non-Hodgkin's lymphoma; lymphocytic leukemia; metastatic renal cell carcinoma; malignant gliomas.

Pulmonary Medicine: Mycoplasma infection in children with asthma; scleroderma lung study; studies in cystic fibrosis.

Rheumatology: Pain perception and responses in fibromyalgia; outcome of systemic lupus erythematosus (SLE) in minorities; central factors in etiopathogenesis of fibromyalgia; genetics of SLE; periodontal disease and rheumatoid arthritis; modifiable risk factors for adverse outcomes in SLE; genetic risk factors for infection in SLE; longitudinal evaluation of African Americans with rheumatoid arthritis; pneumococcal vaccine in rheumatoid arthritis.

Contact Information

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