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National Center for Research Resources, National Institutes of Health. Providing clinical and translational researchers with the training and tools they need to transform basic discoveries into improved human health.

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NCRR's Division for Clinical Research Resources provides funding to biomedical research institutions to establish and maintain specialized clinical research facilities and clinical-grade biomaterials that enable clinical and patient-oriented research.

NCRR's Division for Clinical Research Resources provides funding to biomedical research institutions to establish and maintain specialized clinical research facilities and clinical-grade biomaterials that enable clinical and patient-oriented research.

NCRR's Division for Clinical Research Resources provides funding to biomedical research institutions to establish and maintain specialized clinical research facilities and clinical-grade biomaterials that enable clinical and patient-oriented research.

NCRR's Division for Clinical Research Resources provides funding to biomedical research institutions to establish and maintain specialized clinical research facilities and clinical-grade biomaterials that enable clinical and patient-oriented research.

NCRR's Division for Clinical Research Resources provides funding to biomedical research institutions to establish and maintain specialized clinical research facilities and clinical-grade biomaterials that enable clinical and patient-oriented research.

North Carolina

Wake Forest University School of Medicine

General Clinical Research Center
Wake Forest University School of Medicine
Medical Center Boulevard
Winston-Salem, NC 27157

Web site: www.gcrc.wfubmc.edu external link, opens in new window

Grant No. M01 RR07122

Special Resources, Instruments, or Services

Ankle and brachial blood pressure indices
Anthropometry
Bronchoscopy
Chemotherapy
Clinical breast exams
Cognitive testing
Computerized diet planning for balanced, constant and weighed diets
Conscious sedation

Food frequency administration and analysis
Geriatric GCRC
Hewlett-Packard monitor for blood pressure, respiration, pulse oximetry and cardiac rhythms
Intravenous and oral glucose tolerance testing
Metabolic research kitchen
Nutrition data system for research
Nutrition education
Stress testing


Major Areas of Investigation

Anesthesiology: New spinal anesthetic agents for childbirth and chronic pain.

Cardiovascular Diseases: Treatments for peripheral arterial disease; hypertension and salt sensitivity; exercise training and congestive heart failure; multiethnic study of atherosclerosis; ACE inhibition and novel cardiovascular risk factors; diastolic heart failure.

Dermatology: Psoriasis; reinforcing properties of UV light in tanning bed users.

Endocrinology: Diabetes prevention trial; inhaled insulin versus subcutaneous insulin therapy in diabetes; LDL cholesterol-lowering drugs in hypercholesterolemia.

Gastroenterology: Responses to dietary fat and cholesterol; oxalate studies; virtual colonoscopy.

Genetics: Genetic epidemiology of diabetic cardiovascular disease; molecular epidemiology of breast cancer and prostate cancer; genes and chronic obstructive pulmonary disease; genetics of bone in type 2 diabetes.

Geriatrics and Gerontology: Arthritis, diet, and activity promotion; depression in the elderly; resistance training in older adults; diet, exercise, and metabolism in older women.

Hematology and Oncology: Prostate cancer prevention; diphtheria fusion toxin therapy of myeloid leukemia; recovery in breast cancer; chemotherapy-induced cardiomyopathy and MRI.

Infectious Diseases: Cellular mechanisms of septic shock.

Nephrology: Hemodialysis and quality of life; progression of renovascular disease in the elderly.

Neurology: Treatment of chronic inflammatory demyelinating polyneuropathy; amyotrophic lateral sclerosis; Huntington's disease.

Obstetrics and Gynecology: Ovarian cancer screening study; fatty acids and preterm birth; folic acid load in pregnant epileptic women.

Pediatrics: Ventilation in very-low-birthweight infants; cystic fibrosis, sinusitis; bone strength in children; effect of postnatal dexamethasone on children at school age.

Physiology and Pharmacology: Regional brain activation during cocaine abstinence.

Psychiatry: Optimization of electroconvulsive therapy for depression.

Pulmonary Diseases: Lipid pathways and lung injury; asthma studies; lung cancer screening.

Rheumatology: Systemic lupus erythematosus; T cells.

Urology: Role of oxalate in nephrolithiasis.

Women's Health: Women's Health Initiative (WHI); WHI memory study (WHIMS).

Contact Information

For information about this GCRC and how to access its resources, please contact:

Administrative Director
Marcy Poletti, R.N., M.S.N.
336-716-9755; Fax: 336-716-5055
E-mail: mpoletti@wfubmc.edu

Program Director
Charles E. McCall, M.D.
336-716-4584; Fax: 336-716-3825
E-mail: chmcall@wfubmc.edu

Principal Investigator
William B. Applegate, M.D.
336-716-3430; Fax: 336-716-5139
E-mail: wapplega@wfubmc.edu

Associate Program Director
John R. Crouse III, M.D.
336-716-2076; Fax: 336-716-6164
E-mail: jrcrouse@wfubmc.edu

Associate Program Director
Richard B. Weinberg, M.D.
336-716-4638; Fax: 336-716-6376
E-mail: weinberg@wfubmc.edu

Associate Program Director
Jeff D. Williamson, M.D.
336-713-8583; Fax: 336-713-8800
E-mail: jwilliam@wfubmc.edu

Research Subject Advocate
Susan Margitic, M.S.
336-716-5647; Fax: 336-716-0395
E-mail: smargitic@wfubmc.edu

GCRC Advisory Committee Chairperson
R. Duncan Hite, M.D.
336-716-9442; Fax: 336-716-7277
E-mail: dhite@wfubmc.edu

Research Nurse Manager
Marcy Poletti, R.N., M.S.N.
336-716-9755; Fax: 336-716-5055
E-mail: mpoletti@wfubmc.edu

Bionutrition Research Manager
Linda Easter, R.D., M.S., L.D.N.
336-716-6355; Fax: 336-716-5055
E-mail: leaster@wfubmc.edu

Processing Lab Manager
Marcia Burris
336-716-2676; Fax: 336-716-5055
E-mail: mburris@wfubmc.edu

Molecular Genetics Core Director
Donald W. Bowden, Ph.D.
336-713-7507; Fax: 336-716-5055
E-mail: dbowden@wfubmc.edu

Biostatistician
Timothy Morgan, Ph.D.
336-713-3829; Fax: 336-713-3806
E-mail: tomorgan@wfubmc.edu

Informatics Core Manager
Robert Amoroso
336-716-7786; Fax: 336-716-5055
E-mail: bamoroso@wfubmc.edu


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