New York

The Feinstein Institute for Medical Research

General Clinical Research Center
350 Community Drive
Manhasset, NY 11030

Web site: http://www.nslij.com/body.cfm?id=2737&oTopID=2581&PLinkID=5096

Grant No. M01 RR018535

Special Assays, Services, or Tests

Biorepository core and tissue donation program: Tissues: site initiation (find a source for samples), collection; access to existing samples; Biorepository (stores biological fluids long-term or short-term): plasma, serum, DNA Imaging core: PET scans, MRI scans, fMRI

Molecular biology and immunology core: DNA synthesis of custom oligonucleotides <120 bp in length; standard oligonucleotides; single fluorescently labeled oligonucleotide; double fluorescently labeled oligonucleotide; DNA sequencing; protein sequencing; protein synthesis, 15-20 amino acid residue oligomers; real-time or quantitative PCR; confocal microscope; Hewlett-Packard matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrophotometer; gas chromatograph/mass spectrophotometer; ProteinChip protein analysis system; Sorvall centrifuges, scintillation counter; Bio-Rad gel system, lyophilizer, Shimadzu biospectrophotometer, Savant; automated speed-vac system, dark room, radioactive fume hood; flow cytometry; cytokine ELISA; RNA i solation; silver nitrate immunoperoxidase (SNIP) analysis

Major Areas of Investigation

Cardiology: Cardiac surgery; thyroid hormone therapy.

Endocrinology: Diabetes.

Gastroenterology: Inflammatory bowel disease.

Hematology: Diamond-Blackfan.

Immunology: Chronic lymphomic leukemia; rheumatoid arthritis.

Molecular Genetics: Rheumatoid arthritis; systemic lupus erythematosus; cancer.

Nephrology: Congenital uropathies; diarrhea-related hemolytic uremic syndrome (D-HUS).

Neuropsychiatry: Parkinson's disease; Alzheimer's disease.

Psychiatry: Schizophrenia; depression; post-traumatic disorder; bipolar disorder; autism; obsessive compulsive disorder.

Sepsis: Cytokine responses; HMGB1; cholinergic anti-inflammatory pathway.

Urology: Cystitis; urinary incontinence.

Vascular Disease: Abdominal aortic aneurysm; peripheral vascular disease; carotid endardectomy.

Contact Information

For information about this GCRC and how to access its resources, please contact:

State University of New York, Stony Brook

General Clinical Research Center
University Hospital, 12 South
Stony Brook, NY 11794

Grant No. M01 RR10710

Special Assays, Services, or Tests

Biostatistics and informatics

Gas chromatography/mass spectrometry is available to measure enrichment of stable isotopes in physiological samples derived from metabolic tracer studies

Genetics core laboratory offers genetic testing for well-characterized human genetic disorders. Quality assurance, sample handling and processing, and compliance issues have been established. Isolation and storage of DNA from patient peripheral blood leukocytes; storage and tracking of patient material; assistance with techniques of genetic mutation identification (oligonucleotide primer generation); Epstein-Barr virus (EBV) transformation of lymphocytes for rare human disorders, storage of lymphocytes; DNA sequence analysis

Immuno- and radiometric assays for insulin-like growth factors I and II; insulin-like growth factor binding protein_{1, 2, 3} ; growth hormone, prolactin, catecholamines, dopamine

Outreach program to recruit minorities and women

Major Areas of Investigation

Aging: Regulation of muscle metabolism; effects of GH on immune function.

Diabetes: Genetic studies in patients with type 2 diabetes mellitus; role of the kidney in glucose metabolism.

Dupuytren's Disease: Medical therapy.

Genetics: Hematologic diseases and stroke.

HIV Disease: Pathogenesis of the metabolic complications.

Metabolism: Regulation of muscle wasting in catabolic illness; regulation of muscle metabolism by insulin and amino acids in normal adults; effects of dietary arginine supplements on metabolism in cancer patients; gut priming in neonatal adaptation to enteral nutrition in micropreemies.

Neurology: Neurologic complications and development of novel diagnostic testing for Lyme disease; cognitive dysfunction in multiple sclerosis.

Osteoporosis: Development of new therapeutic agents.

Psychiatry: Substance abuse and its effects on the brain dopamine system.

Renal Failure: Use of anabolic agents in children with chronic renal failure; role of nitric oxide in defense against infection in patients on peritoneal dialysis.

Contact Information

For information about this GCRC and how to access its resources, please contact: