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National Center for Research Resources, National Institutes of Health. Providing clinical and translational researchers with the training and tools they need to transform basic discoveries into improved human health.

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Notice: As of December 23, 2011, all NCRR programs have been transferred to other NIH Institutes and Centers.
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NCRR's Division of Biomedical Technology supports research to develop innovative technologies and helps make them accessible to the biomedical research community.

NCRR's Division of Biomedical Technology supports research to develop innovative technologies and helps make them accessible to the biomedical research community.

NCRR's Division of Biomedical Technology supports research to develop innovative technologies and helps make them accessible to the biomedical research community.

NCRR's Division of Biomedical Technology supports research to develop innovative technologies and helps make them accessible to the biomedical research community.

NCRR's Division of Biomedical Technology supports research to develop innovative technologies and helps make them accessible to the biomedical research community.

Shared Instrumentation

Results

Recent research supported by NCRR's Shared and High-End Instrumentation grant programs

Synthesis, purification, and characterization of single helix membrane peptides and proteins for NMR spectroscopyexternal link, opens in new window
Methods Mol Biol

Mapping the organization of axis of motion selective features in human area MT using high-field fMRIexternal link, opens in new window
PLoS One

Non-steroidal anti-inflammatory drugs target the pro-tumorigenic extracellular matrix of the postpartum mammary glandexternal link, opens in new window
Int J Dev Biol

Purification of CFTR for mass spectrometry analysis: identification of palmitoylation and other post-translational modificationsexternal link, opens in new window
Protein Eng Des Sel

Native ultrastructure of the red cell cytoskeleton by cryo-electron tomographyexternal link, opens in new window
Biophys J

A typical preparation of Francisella tularensis O-antigen yields a mixture of three types of saccharidesexternal link, opens in new window
Biochemistry

Multimodal quantitative magnetic resonance imaging of thalamic development and aging across the human lifespan: implications to neurodegeneration in multiple sclerosisexternal link, opens in new window
J Neurosci

Dynamics of tandem bubble interaction in a microfluidic channelexternal link, opens in new window
J Acoust Soc Am

Removal of the basement membrane enhances corneal wound healingexternal link, opens in new window
Exp Eye Res

Affinity-based profiling of dehydrogenase subproteomesexternal link, opens in new window
Methods Mol Biol

A chemical proteomic probe for detecting dehydrogenases: catechol rhodanineexternal link, opens in new window
Methods Mol Biol

Structural basis of p38a regulation by hematopoietic tyrosine phosphataseexternal link, opens in new window
Nat Chem Biol

Imaging in sarcomaexternal link, opens in new window
J Nucl Med

Two-photon microscopy of cortical NADH fluorescence intensity changes: correcting contamination from the hemodynamic responseexternal link, opens in new window
J Biomed Opt

Phosphatidylinositol induces fluid phase formation and packing defects in phosphatidylcholine model membranesexternal link, opens in new window
Chem Phys Lipids

Metal ion binding and function in natural and artificial small RNA enzymes from a structural perspectiveexternal link, opens in new window
Met Ions Life Sci

On the nature of C-H···F-C interactions in hindered CF3-C(sp3) bond rotationsexternal link, opens in new window
Angew Chem Int Ed Engl

Arginine residues are more effective than lysine residues in eliciting the cellular uptake of onconaseexternal link, opens in new window
Biochemistry

A reduced-amide inhibitor of Pin1 binds in a conformation resembling a twisted-amide transition stateexternal link, opens in new window
Biochemistry

The NLRP12 pyrin domain: structure, dynamics, and functional insightsexternal link, opens in new window
J Mol Biol

Deoxyguanosine forms a bis-adduct with E,E-muconaldehyde, an oxidative metabolite of benzene: implications for the carcinogenicity of benzeneexternal link, opens in new window
Chem Res Toxicol

Artifact quantification and tractography from 3T MRI after placement of aneurysm clips in subarachnoid hemorrhage patientsexternal link, opens in new window
BMC Med Imaging

Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clockexternal link, opens in new window
Science

Reversible cardiac conduction block and defibrillation with high-frequency electric fieldexternal link, opens in new window
Sci Transl Med

Influence of host phylogeographic patterns and incomplete lineage sorting on within-species genetic variability in Wigglesworthia species, obligate symbionts of tsetse fliesexternal link, opens in new window
Appl Environ Microbiol

Dynamics of calcium sparks and calcium leak in the heartexternal link, opens in new window
Biophys J

Highly diastereoselective and general synthesis of primary ß-fluoroaminesexternal link, opens in new window
Org Lett

Quantitative radiology: automated CT liver volumetry compared with interactive volumetry and manual volumetryexternal link, opens in new window
AJR Am J Roentgenol

Identifying transient protein-protein interactions in EphB2 signaling by blue native PAGE and mass spectrometryexternal link, opens in new window
Proteomics

Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteinsexternal link, opens in new window
J Am Chem Soc

See more NCRR instrumentation-related publications on the National Library of Medicine's PubMedexternal link, opens in new window

NOTICE TO APPLICANTS & GRANTEES: The Shared Instrumentation Grant program continues to operate on its regular schedule. The FY 2013 SIG Program Announcement external link, opens in new window has been published in the NIH Guide for Grants and Contracts.

On September 2, 2011, Dr. Marjorie A. Tingle, director of the Shared Instrumentation Grant (SIG) program and the High-End Instrumentation (HEI) grant program, departed from federal service at NCRR. Dr. Abraham Levy is the acting program director, working closely with program officer Dr. Christina Liu. Their contact information is provided below. Any changes in assignment of management of your S10 grant or application will be reflected in your eRA Commons account.

NCRR's Shared Instrumentation Grant (SIG) program supports the purchase of research equipment in the $100,000 to $600,000 price range. Examples of instrumentation supported by SIG funding include nuclear magnetic resonance systems, electron and confocal microscopes, mass spectrometers, protein and DNA sequencers, biosensors, X-ray diffractometers and cell sorters.

From FY 2000 to FY 2011, the SIG program provided 1,503 awards to biomedical research institutions in 45 states and the District of Columbia, totaling $507,711,280.

Awards

Purpose

The SIG program provides a cost-effective mechanism for groups of NIH-supported investigators to obtain commercially-available equipment that costs more than $100,000. Instruments in this price range are typically too expensive to be obtained through a research project grant. The maximum SIG award is $600,000. These grants cover the direct costs of the instruments; the grantee institution must meet costs for maintenance, service contracts, and technical support. Awards are for one year only and are not renewable.

Eligibility Requirements

SIG awards are made to domestic public and non-profit institutions, including health professional schools, graduate institutions, hospitals, health departments and research organizations. To be eligible for a SIG, an institution must identify three or more major users of the technology who are principal investigators on active NIH awards funded through the P01, R01, U01, R35, R37, DP1 or DP2 mechanisms. However, the principal investigator of the SIG itself does not have to be NIH funded.

How to Apply

SIG applications are submitted to NIH electronically through Grants.govexternal link, opens in new window, using the SF 424 Research and Related formsexternal link, opens in new window. The application receipt date is once a year, usually in March. Detailed information is available in the most recent SIG program announcementexternal link, opens in new window.

Because the SIG program interfaces with other NCRR and NIH grant programs, potential applicants are strongly encouraged to contact the SIG program director before submitting a proposal.

Frequently Asked Questions

Click here to view Frequently Asked Questions.

Forms for Grantees

Contact Information

For further information about NCRR support for shared instrumentation, contact:

Abraham Levy, Ph.D.
Acting Program Director, Shared Instrumentation Grant Program
Division of Biomedical Technology
National Center for Research Resources
National Institutes of Health
One Democracy Plaza, Room 970
6701 Democracy Boulevard, MSC 4874
Bethesda, Maryland 20892-4874 (20817 for express mail)
Telephone: 301-435-0772
Fax: 301-480-3659
E-mail: Abraham.Levy

Christina H. Liu, Ph.D., P.E.
Program Officer, Shared Instrumentation Grant Program
Division of Biomedical Technology
National Center for Research Resources
National Institutes of Health
One Democracy Plaza, Room 964
6701 Democracy Boulevard, MSC 4874
Bethesda, Maryland 20892-4874 (20817 for express mail)
Telephone: 301-435-0755
Fax: 301-480-3659
E-mail: Christina.Liu

National Center for Research Resources • 6701 Democracy Boulevard MSC 4874 • Bethesda MD 20892-4874 • 301-435-0888
 
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