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National Center for Research Resources, National Institutes of Health. Providing clinical and translational researchers with the training and tools they need to transform basic discoveries into improved human health.

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Notice: As of December 23, 2011, all NCRR programs have been transferred to other NIH Institutes and Centers.
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NCRR's Division of Biomedical Technology supports research to develop innovative technologies and helps make them accessible to the biomedical research community.

NCRR's Division of Biomedical Technology supports research to develop innovative technologies and helps make them accessible to the biomedical research community.

NCRR's Division of Biomedical Technology supports research to develop innovative technologies and helps make them accessible to the biomedical research community.

NCRR's Division of Biomedical Technology supports research to develop innovative technologies and helps make them accessible to the biomedical research community.

NCRR's Division of Biomedical Technology supports research to develop innovative technologies and helps make them accessible to the biomedical research community.

High-End Instrumentation

Results

Recent research supported by NCRR's Shared and High-End Instrumentation grant programs

Synthesis, purification, and characterization of single helix membrane peptides and proteins for NMR spectroscopyexternal link, opens in new window
Methods Mol Biol

Mapping the organization of axis of motion selective features in human area MT using high-field fMRIexternal link, opens in new window
PLoS One

Non-steroidal anti-inflammatory drugs target the pro-tumorigenic extracellular matrix of the postpartum mammary glandexternal link, opens in new window
Int J Dev Biol

Purification of CFTR for mass spectrometry analysis: identification of palmitoylation and other post-translational modificationsexternal link, opens in new window
Protein Eng Des Sel

Native ultrastructure of the red cell cytoskeleton by cryo-electron tomographyexternal link, opens in new window
Biophys J

A typical preparation of Francisella tularensis O-antigen yields a mixture of three types of saccharidesexternal link, opens in new window
Biochemistry

Multimodal quantitative magnetic resonance imaging of thalamic development and aging across the human lifespan: implications to neurodegeneration in multiple sclerosisexternal link, opens in new window
J Neurosci

Dynamics of tandem bubble interaction in a microfluidic channelexternal link, opens in new window
J Acoust Soc Am

Removal of the basement membrane enhances corneal wound healingexternal link, opens in new window
Exp Eye Res

Affinity-based profiling of dehydrogenase subproteomesexternal link, opens in new window
Methods Mol Biol

A chemical proteomic probe for detecting dehydrogenases: catechol rhodanineexternal link, opens in new window
Methods Mol Biol

Structural basis of p38a regulation by hematopoietic tyrosine phosphataseexternal link, opens in new window
Nat Chem Biol

Imaging in sarcomaexternal link, opens in new window
J Nucl Med

Two-photon microscopy of cortical NADH fluorescence intensity changes: correcting contamination from the hemodynamic responseexternal link, opens in new window
J Biomed Opt

Phosphatidylinositol induces fluid phase formation and packing defects in phosphatidylcholine model membranesexternal link, opens in new window
Chem Phys Lipids

Metal ion binding and function in natural and artificial small RNA enzymes from a structural perspectiveexternal link, opens in new window
Met Ions Life Sci

On the nature of C-H···F-C interactions in hindered CF3-C(sp3) bond rotationsexternal link, opens in new window
Angew Chem Int Ed Engl

Arginine residues are more effective than lysine residues in eliciting the cellular uptake of onconaseexternal link, opens in new window
Biochemistry

A reduced-amide inhibitor of Pin1 binds in a conformation resembling a twisted-amide transition stateexternal link, opens in new window
Biochemistry

The NLRP12 pyrin domain: structure, dynamics, and functional insightsexternal link, opens in new window
J Mol Biol

Deoxyguanosine forms a bis-adduct with E,E-muconaldehyde, an oxidative metabolite of benzene: implications for the carcinogenicity of benzeneexternal link, opens in new window
Chem Res Toxicol

Artifact quantification and tractography from 3T MRI after placement of aneurysm clips in subarachnoid hemorrhage patientsexternal link, opens in new window
BMC Med Imaging

Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clockexternal link, opens in new window
Science

Reversible cardiac conduction block and defibrillation with high-frequency electric fieldexternal link, opens in new window
Sci Transl Med

Influence of host phylogeographic patterns and incomplete lineage sorting on within-species genetic variability in Wigglesworthia species, obligate symbionts of tsetse fliesexternal link, opens in new window
Appl Environ Microbiol

Dynamics of calcium sparks and calcium leak in the heartexternal link, opens in new window
Biophys J

Highly diastereoselective and general synthesis of primary ß-fluoroaminesexternal link, opens in new window
Org Lett

Quantitative radiology: automated CT liver volumetry compared with interactive volumetry and manual volumetryexternal link, opens in new window
AJR Am J Roentgenol

Identifying transient protein-protein interactions in EphB2 signaling by blue native PAGE and mass spectrometryexternal link, opens in new window
Proteomics

Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteinsexternal link, opens in new window
J Am Chem Soc

See more NCRR instrumentation-related publications on the National Library of Medicine's PubMedexternal link, opens in new window

NOTICE TO GRANTEES: On September 2, 2011, Dr. Marjorie A. Tingle, director of the Shared Instrumentation Grant (SIG) program and the High-End Instrumentation (HEI) grant program, departed from federal service at NCRR. Dr. Abraham Levy is the acting program director, working closely with program officer Dr. Christina Liu. Their contact information is provided below. Any changes in assignment of management of your S10 grant or application will be reflected in your eRA Commons account.

NCRR's High-End Instrumentation (HEI) grant program supports the purchase of a single major piece of research equipment that costs more than $750,000. Instruments in this price range include structural and functional imaging systems, macromolecular NMR spectrometers, high-resolution mass spectrometers, electron microscopes, and supercomputers.

Since its inception in 2002, the HEI Program has provided 140 awards to biomedical research institutions in 27 states, totaling $224,088,003.

Awards

Purpose

Rapid technological development has led to the production of a new generation of instruments. These high-sensitivity, high-resolution instruments can accelerate the rate at which researchers can acquire, analyze, display, and understand data. To assist NIH-supported investigators to keep at the forefront of modern biology and medicine, in 2002 NCRR began the HEI grant program. HEI awards, which are for one year and are not renewable, provide support for up to a maximum of $2.0 million in direct costs for a single major piece of research equipment. The floor is set at $750,000. The HEI grant program complements the Shared Instrumentation Grant program.

Eligibility Requirements

  • Institutions: HEI grants are awarded to domestic public and non-profit health professional schools, other academic institutions, hospitals, health departments, and research organizations. It is anticipated that only a few grants will be awarded in a given technological area.

  • Applicants: The instrument must be shared by a minimum of three principal investigators on NIH peer-reviewed research grants awarded through the following NIH funding mechanisms: P01, R01, U01, R35, R37, DP1 and DP2. Once this eligibility requirement has been met, additional users with other types of active NIH research grants mechanisms (such as but not limited to R03, R21, R55, RC, RL, P30, P41 and P50) can be added as major or minor users. NIH training grants and contracts are not eligible. Applicants must demonstrate a clear need for the requested instrumentation, ensuring that at least 75 percent of the total usage time will be for projects supported by NIH research grants.

Awards are for one year, and matching funds are not required. However, NCRR expects institutions that compete for HEI awards to provide an appropriate level of support for associated infrastructure, such as building alterations or renovations, technical personnel, and post-award service contracts for instrument maintenance and operation.

How to Apply

The HEI program is only offered every other year. A Program Announcement for the HEI program is published in a June issue of the NIH Guide for Grants and Contracts (http://grants1.nih.gov/grants/guide/index.htmlexternal link, opens in new window) with a receipt date in September. This announcement includes information on the research objectives, eligibility criteria, application and review procedures, award criteria, and contact information. HEI applications are submitted to NIH electronically through Grants.govexternal link, opens in new window using the SF 424 Research and Related formsexternal link, opens in new window. Detailed information is available in the most recent HEI program announcementexternal link, opens in new window.

Because the HEI program interfaces with other NCRR and NIH grant programs, potential applicants are strongly encouraged to contact the HEI program director before submitting a proposal.

Forms for Grantees

Contact Information

For further information about NCRR support for high-end instrumentation, contact:

Abraham Levy, Ph.D.
Acting Program Director, Shared Instrumentation Grant Program
Division of Biomedical Technology
National Center for Research Resources
National Institutes of Health
One Democracy Plaza, Room 970
6701 Democracy Boulevard, MSC 4874
Bethesda, Maryland 20892-4874 (20817 for express mail)
Telephone: 301-435-0772
Fax: 301-480-3659
E-mail: Abraham.Levy

Christina H. Liu, Ph.D., P.E.
Program Officer, Shared Instrumentation Grant Program
Division of Biomedical Technology
National Center for Research Resources
National Institutes of Health
One Democracy Plaza, Room 964
6701 Democracy Boulevard, MSC 4874
Bethesda, Maryland 20892-4874 (20817 for express mail)
Telephone: 301-435-0755
Fax: 301-480-3659
E-mail: Christina.Liu

National Center for Research Resources • 6701 Democracy Boulevard MSC 4874 • Bethesda MD 20892-4874 • 301-435-0888
 
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